The posterior probabilities are represented by circles drawn in scale in the nodes. The maximum clade credibility tree inferred using 125 Yellow fever virus sequences (651 nt) from South America is shown. S3 Fig: Phylogenetic analyses of Yellow fever virus (based on dataset 2). The municipalities where human or non-human samples were collected are indicated by dots and respective names. Red: municipalities with vaccination coverage ≤50% yellow: municipalities with vaccination coverage between 50% and 95%, and green: municipalities with vaccination coverage equal or above 95%. Map of Minas Gerais State showing the vaccination coverage per municipatilty in 2016 (data available at, accessed at April 20th, 2018). Data regarding the number of yellow fever cases were obtained from Sistema de Informação de Agravos de Notificação (SINAN) and official bulletins from Ministry of Health, Brazil. *data from May 2016 to July 2017 and ** data from July 2017 to February 2018. The Brazilian regions and the bars representing the numbers of yellow fever human cases are colored accordingly. The y-axis is shown in logarithmic scale and indicates the number of cases per year. (B) Number of sylvatic yellow fever human cases, from 2001 to February 2018, according to the regions of Brazil. The map was done using QGIS v.2.18.16 and information from Instituto Brasileiro de Geografia e Estatística and Ministério do Meio Ambiente. Federal District and States are represented by initials, as follows: AC: Acre AL: Alagoas AP: Amapá AM: Amazonas BA: Bahia CE: Ceará DF: Distrito Federal: ES: Espírito Santo GO: Goiás MA: Maranhão MT: Mato Grosso MS: Mato Grosso do Sul MG: Minas Gerais PA: Pará PB: Paraíba PR: Paraná PE: Pernambuco PI: Piauí RR: Roraima RO: Rondônia RJ: Rio de Janeiro RN: Rio Grande do Norte RS: Rio Grande do Sul SC: Santa Catarina SP: São Paulo SE: Sergipe and TO: Tocantins. Brazilian geopolitical regions are colored as follows: North region in blue, Northeast region in dark orange, Southeast region in green, South region in purple, and Midwest region in red.
The Amazon Basin, where sylvatic yellow fever is endemic, is highlighted.
(A) Geopolitical map of Brazil and the Amazon Basin. S1 Fig: Historical data of yellow fever in Brazil. Izabela Maurício de Rezende, Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing, # 1 Lívia Sacchetto, Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing, # 1 Érica Munhoz de Mello, Methodology, Resources, Writing – review & editing, 2 Pedro Augusto Alves, Methodology, Supervision, Writing – review & editing, 3 Felipe Campos de Melo Iani, Methodology, Resources, Writing – review & editing, 4 Talita Émile Ribeiro Adelino, Methodology, Resources, 4 Myrian Morato Duarte, Methodology, Writing – review & editing, 4 Ana Luísa Furtado Cury, Methodology, Resources, 4 André Felipe Leal Bernardes, Methodology, Resources, 4 Tayrine Araújo Santos, Methodology, Resources, 5 Leonardo Soares Pereira, Investigation, Resources, Writing – review & editing, 5 Maria Rita Teixeira Dutra, Investigation, Resources, Writing – review & editing, 5 Dario Brock Ramalho, Investigation, Resources, Writing – review & editing, 5 Benoit de Thoisy, Funding acquisition, Investigation, Writing – original draft, Writing – review & editing, 6 Erna Geessien Kroon, Funding acquisition, Investigation, Writing – original draft, 1 Giliane de Souza Trindade, Conceptualization, Funding acquisition, Investigation, Writing – original draft, Writing – review & editing, 1 and Betânia Paiva Drumond, Conceptualization, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Supervision, Writing – original draft, Writing – review & editing 1, *
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